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KMID : 0043320140370040452
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Archives of Pharmacal Research
2014 Volume.37 No. 4 p.452 ~ p.458
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Synthesis of novel 3-allylseleno-6-alkylthiopyridazines: their anticancer activity against MCF-7 cells
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Kim Chae-Won
Kim Saet-Byeul
Park Myung-Sook
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Abstract
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A new series of 3-allylseleno-6-alkylthiopyridazines 6a?6g was synthesized by two synthetic routes from 3,6-dichloropyridazine to develop new anticancer agents. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Compound 6e (3-allylseleno-6-pentylthiopyridazine) showed higher potency than 5FU for inhibiting the growth of these cell lines. This suggests the potential anticancer activity of compound 6e.
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KEYWORD
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Allylselenopyridazines, Pyridazines, Organoseleniums, Anticancer activities, MCF-7 cells
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